منابع مشابه
Update on HIV reservoirs
The stable latent reservoir for HIV-1 in resting memory CD4 T cells is a major barrier to curing HIV-1/AIDS. Studies on HIV-1 latency focused on regulation and reactivation of viral gene expression in the cells in which viral latent infection is already established. However, it is not well understood how virus becomes latent. In this study, we found that in a subset of memory precursor CD4 T ce...
متن کاملCellular and anatomical reservoirs of HIV-1 in patients receiving potent antiretroviral combination therapy.
The eradication of human immunodeficiency virus 1 (HIV-1) from infected persons is the ultimate goal of HIV therapeutic interventions. Great strides have been made in developing potent antiretroviral regimens that greatly suppress HIV-1 replication. Despite these therapeutic advances, major obstacles remain to eradicating HIV-1. Reservoirs of HIV-1 have been identified that represent major impe...
متن کاملHIV Persistence and Viral Reservoirs
Although antiretroviral therapy (ART) can effectively inhibit replication of human immunodeficiency virus type 1 (HIV-1), the virus is able to persist in cellular and anatomical viral reservoirs. Latently infected resting memory CD4 T-cells are an important cellular reservoir, and the central nervous system (CNS) an important anatomical reservoir for HIV-1 infection. The overall aim of this the...
متن کاملHow to best measure HIV reservoirs?
PURPOSE OF REVIEW The persistence of HIV within infected CD4 T cells is a major obstacle to eradication, and assessment of the strategies to reduce HIV reservoirs is one of the major challenges. Measuring HIV reservoirs accurately will be necessary to assess those strategies. The objective of this review is to present the most recent studies that may help to define the best markers to measure H...
متن کاملCNS reservoirs for HIV: implications for eradication
Controversy exists as to whether the central nervous system (CNS) serves as a reservoir site for HIV, in part reflecting the varying perspectives on what constitutes a 'reservoir' versus a mere site of latent viral integration. However, if the CNS proves to be a site of HIV persistence capable of replicating and reseeding the periphery, leading to failure of virological control, this privileged...
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ژورنال
عنوان ژورنال: AIDS
سال: 2016
ISSN: 0269-9370
DOI: 10.1097/qad.0000000000001281